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Sam's News — diet-exercise — 2026-08-29

Diet & Metabolism

7.5 Ketogenic diet reduces liver fat by 67% in clinical trial

A ketogenic diet reduced liver fat by 67% in people with obesity and fatty liver disease, significantly outperforming Mediterranean (45% reduction) and low-fat diets in a clinical trial. All three groups lost approximately 10% of body weight over four to five months, with about half of ketogenic participants no longer meeting prediabetes criteria.

  • 67% liver fat reduction on ketogenic diet vs. 45% on Mediterranean and low-fat diets
  • Ketogenic diet: 4% carbs, 73% fat; Mediterranean: 50% carbs, 35% fat; Low-fat: 70% carbs, 15% fat
  • All groups achieved ~10% body weight loss over 4–5 months
  • ~50% of ketogenic group reversed prediabetes status
  • Published August 27, 2026, in Cell Metabolism; led by Samuel Klein at Washington University

Sources: ScienceDaily AI Web Searched, ScienceDaily — Health RSS, ScienceDaily — Fitness RSS, ScienceDaily — Nutrition RSS

Health Risk

7 Long-term melatonin use linked to 90% higher heart failure risk

A large preliminary study found chronic insomnia patients using melatonin long-term had approximately 90% higher risk of developing heart failure over five years. The findings raise questions about the long-term safety of the over-the-counter supplement, which lacks FDA regulation for strength and purity.

  • 90% elevated heart failure risk over 5 years in chronic melatonin users with insomnia
  • Associations also found with heart failure hospitalization and all-cause mortality
  • Data from TriNetX Global Research Network covering electronic health records
  • Study does not establish causation
  • OTC melatonin supplements lack FDA regulation for potency consistency

Sources: ScienceDaily AI Web Searched, ScienceDaily — Health RSS, ScienceDaily — Nutrition RSS